grinding method in green chemistry

  • A simplified green chemistry approach to the Biginelli

    Grindstone Chemistry––a greatly evolved version of Toda’s method of grinding solids together for solvent-free chemical reactions––has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones.

    • Cited by: 195

  • Green chemistry Wikipedia

    Green chemistry, also called sustainable chemistry, is an area of chemistry and chemical engineering focused on the designing of products and processes that minimize or eliminate the use and generation of hazardous substances. While environmental chemistry focuses on the effects of polluting chemicals on nature, green chemistry focuses on the environmental impact of chemistry, including

  • (PDF) Grinding as Solvent-Free Green Chemistry Approach

    Grinding as Solvent-Free Green Chemistry Approach for Cyclodextrin Inclusion Complex Preparation in the Solid State. sustainable, and eco-friendly solvent-free method. This review is intended

  • (PDF) Green Chemistry in Organic Synthesis

    The development of the concepts for “Green Chemistry” and the main principles of this field are reviewed. Examples of the application of these principles in different areas of chemistry are

  • Grinding as Solvent-Free Green Chemistry Approach for

    pharmaceutics Review Grinding as Solvent-Free Green Chemistry Approach for Cyclodextrin Inclusion Complex Preparation in the Solid State Mario Jug 1 and Paola Angela Mura 2,* 1 Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovaciˇ ca´ 1, 10000 Zagreb, Croatia; [email protected]

    • Cited by: 3

  • Mechanical Grinding an overview ScienceDirect Topics

    The first approach starts with a solid mass and making it into smaller nanosized particles by applying any mechanical method (i.e., mechanical grinding) and later stabilizing the particles to the required size. However, with this method it is difficult to achieve the expected narrow size.

  • grinding method theory related to organic chemistry

    Mortar-pestle grinding synthetic methods were to avoid solvent. .. Green Chemistry: Theory and Practice, Oxford University Press, New York, NY, USA, 1998. employed. A main obstacle in the manual grinding method is the fact that the Due to effects of crystal packing, homology in solid state is difficult to achieve. We present the

  • Solvent-drop grinding: Green polymorph control of

    Neat grinding method without utilizing any solvents 3,4 or by solvent drop grinding 5,where the small or acceptable amount of solvent is utilized which ultimately evaporate during synthetic

  • grinding method in green chemistry albanometeo.it

    grinding method in green chemistry. Green Chemistry. Green Chemistry. A traditional concept in process chemistry has been the optimization of the time-space yield. From our modern perspective, this limited viewpoint must be enlarged, as for example toxic wastes can destroy natural resources and especially the means of livelihood for future

  • Ball Milling for Heterocyclic Compounds Synthesis in Green

    Ball Milling for Heterocyclic Compounds Synthesis in Green Chemistry: A Review under solvent-free conditions are aimed at green or sustainable chemistry 1,2 because waste and energy costs are

  • Catalyst-free and solvent-free Michael addition of 1,3

    Therefore, we were encouraged to research the Michael addition systematically by the grinding method. Herein, we report a green protocol for the Michael addition of 1,3-dicarbonyl compounds to nitroalkenes under catalyst- and solvent-free conditions (Scheme 1). Utilizing this simple, rapid, low-cost and effective procedure, various nitro

  • Application of grinding method to solid-state organic

    Application of grinding method to solid-state organic synthesis Article in Chinese Journal of Organic Chemistry 25(5):608-613 · May 2005 with 374 Reads How we measure 'reads'

  • Catalyst-free and solvent-free Michael addition of 1,3

    Therefore, we were encouraged to research the Michael addition systematically by the grinding method. Herein, we report a green protocol for the Michael addition of 1,3-dicarbonyl compounds to nitroalkenes under catalyst- and solvent-free conditions . Utilizing this simple, rapid, low-cost and effective procedure, various nitro diketone

  • Green synthesis, molecular docking and anticancer activity

    GREEN CHEMISTRY LETTERS AND REVIEWS 7. group of the bound ATP molecule to the substrate’s serine/threonine/tyrosine residue (Figure 3)(42–47). Result and discussion Condensation of 1,4-dihydropyridine-3,5-dicarbohydra- of glacial acetic acid under grinding method to give

  • Ambient stable naphthalenediimide radical ions: synthesis

    Furthermore, we also realized NDI radical ions in moderate yields by applying ball mill grinding. In addition, we have made an attempt to unearth the most plausible reaction mechanism for these reactions. Importantly, this is the first instance whereby synthetic radical ion chemistry has been brought under the realm of green synthesis.

  • Atom-Efficient, Solvent-Free, Green Synthesis of Chalcones

    Atom-Efficient, Solvent-Free, Green Synthesis of Chalcones by Grinding Nora M. Rateb and Hussein F. Zohdi Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt Abstract: AnimprovedClaisen–Schmidt condensation reaction ofmethyl ketones and aromatic aldehydes can be achieved by grinding at room temperature in the absence of

  • P-ISSN: 2349–8528 E-ISSN: 2321–4902 Green methods for

    vast use of green chemistry in synthesis of heterocyclic compounds. 2.1 Using grinding method Bose et al, 2004 reported the synthesis of ethyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (I) with grinding technique by using Biginelli reaction. This method is simple, easy workup and environmentally benign. NH N H H3C S

  • Grinding Chemicals Together in an Effort to be Greener

    Jul 19, 2016· Grinding Chemicals Together in an Effort to be Greener. “Green chemistry is a recognition that chemistry could do better through design,” said The method not only does away with

  • A green and efficient protocol for the synthesis of

    Nov 25, 2014· A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method. Multi-component reactions (MCRs) are ecofriendly process as they obey green chemistry principles .

  • A simplified green chemistry approach to the Biginelli

    A simplified green chemistry approach to the Biginelli reaction using!Grindstone Chemistry" Ajay K. Bose,a,* Suhas Pednekar,a Subhendu N. Ganguly,a Goutam Chakrabortyb and Maghar S. Manhasa aGeorge Barasch Bioorganic Research Laboratory, Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA

  • Grinding as Solvent-Free Green Chemistry Approach for

    Among the different techniques proposed for preparing cyclodextrin inclusion complex in the solid state, mechanochemical activation by grinding appears as a fast, highly efficient, convenient, versatile, sustainable, and eco-friendly solvent-free method. This review is intended to give a systematic overview of the currently available data in this field, highlighting both the advantages as well

  • Grinding-induced functionalization of carbon-encapsulated

    Covalent functionalization of carbon-encapsulated iron nanoparticles based on the grinding-induced 1,3-cycloaddition reaction of nitrile oxides is presented. We report an easy to perform, fast and efficient method for the direct introduction of various types of functional moieties, such as carboxylic, metall

  • Screening for Pharmaceutical Cocrystal Hydrates via Neat

    May 12, 2007· Overall, liquid-assisted grinding is less sensitive to the form of the reactant (i.e., hydrate or anhydrate) than neat grinding. For that reason liquid-assisted grinding appears to be a more efficient method of screening for cocrystal hydrates, and it is also applicable to screening for hydrates of APIs.

  • The effect of bean origin and temperature on grinding

    Apr 18, 2016· The extraction depends on temperature, water chemistry and also the accessible surface area of the coffee. Here we investigate whether variations in the production processes of single origin coffee beans affects the particle size distribution upon grinding.

  • A green and efficient protocol for the synthesis of

    Nov 25, 2014· A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method. Multi-component reactions (MCRs) are ecofriendly process as they obey green chemistry principles .

  • A simplified green chemistry approach to the Biginelli

    A simplified green chemistry approach to the Biginelli reaction using!Grindstone Chemistry" Ajay K. Bose,a,* Suhas Pednekar,a Subhendu N. Ganguly,a Goutam Chakrabortyb and Maghar S. Manhasa aGeorge Barasch Bioorganic Research Laboratory, Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA

  • Grinding as Solvent-Free Green Chemistry Approach for

    Among the different techniques proposed for preparing cyclodextrin inclusion complex in the solid state, mechanochemical activation by grinding appears as a fast, highly efficient, convenient, versatile, sustainable, and eco-friendly solvent-free method. This review is intended to give a systematic overview of the currently available data in this field, highlighting both the

  • Grinding-induced functionalization of carbon-encapsulated

    Covalent functionalization of carbon-encapsulated iron nanoparticles based on the grinding-induced 1,3-cycloaddition reaction of nitrile oxides is presented. We report an easy to perform, fast and efficient method for the direct introduction of various types of functional moieties, such as carboxylic, metall

  • Screening for Pharmaceutical Cocrystal Hydrates via Neat

    May 12, 2007· Overall, liquid-assisted grinding is less sensitive to the form of the reactant (i.e., hydrate or anhydrate) than neat grinding. For that reason liquid-assisted grinding appears to be a more efficient method of screening for cocrystal hydrates, and it is also applicable to screening for hydrates of APIs.

  • Grinding chemicals together in an effort to be greener

    Jul 19, 2016· The green chemistry movement has motivated some chemists to ditch the old solution methods for mechanochemistry. "Green chemistry is a recognition that chemistry could do better through design

  • The effect of bean origin and temperature on grinding

    Apr 18, 2016· The extraction depends on temperature, water chemistry and also the accessible surface area of the coffee. Here we investigate whether variations in the production processes of single origin coffee beans affects the particle size distribution upon grinding.

  • Radical ion synthesis finally embraces green chemistry

    However, in stark contrast to the green progress made in many areas of organic chemistry, until now, not a single example of a green or environmentally friendly method for making organic radical ion existed. Pritam Mukhopadhyay, of Jawaharlal Nehru University, and his team have spent years investigating radical ion design.

  • NOTES ON GREEN CHEMISTRY green chemistry

    Green chemistry consists of chemicals and chemical processes designed to reduce or eliminate negative environmental impacts. The use and production of these chemicals may involve reduced waste products, non-toxic components, and improved efficiency.

  • An Efficient, Catalytic, Aerobic, Oxidative Iodination of

    Oct 23, 2003· Iodination of industrially important aromatic compounds using N-iodosuccinimide by grinding method. Green Processing and Synthesis 2018, 7 (6),477-486. DOI: 10.1515/gps-2017-0072. Alexandru Popa, Viorel Sasca, Orsina Verdes, Albert Oszko.

  • Catalyst-free and solvent-free Michael addition of 1,3

    ition systematically by the grinding method. Herein, we report a green protocol for the Michael addition of 1,3-dicarbonyl compounds to nitroalkenes under catalyst- and solvent-free conditions (Scheme€1). Utilizing this simple, rapid, low-cost and effective procedure, various nitro diketone deriva-tives were synthesized in high yields.

  • Efficient NaOH-Catalyzed Reaction of Aromatic Aldehyde

    Abstract An efficient and facile synthesis of 2,6-dicyanoanilines via a one-pot reaction of aromatic aldehydes, malononitrile, and cyclic ketones in the presence of NaOH under solvent-free conditions using a grinding method has been developed. Compared with the classical reaction conditions, the new synthetic method has the advantages of excellent yields, shorter reaction

  • Notes and references Royal Society of Chemistry

    Given the current interest in polymorphic systems, these findings suggest important industrial implications. That the transformations occur with minimal solvent addition also indicates a green chemistry application. Further, this approach may represent a novel method of revealing undiscovered metastable crystalline modifications in other systems.

  • Journal of Chemistry Hindawi

    Grinding method is of interest because it is performed in the absence of solvent and under environment-friendly conditions. In the last years, this technique has found interest in synthetic organic chemistry [13–15].